diff --git a/lib/rfnoc/transport_adapters/rfnoc_ta_x4xx_eth/constraints/qsfp_100gbe_port0.xdc b/lib/rfnoc/transport_adapters/rfnoc_ta_x4xx_eth/constraints/qsfp_100gbe_port0.xdc
new file mode 100644
index 0000000..c466d66
--- /dev/null
+++ b/lib/rfnoc/transport_adapters/rfnoc_ta_x4xx_eth/constraints/qsfp_100gbe_port0.xdc
@@ -0,0 +1,11 @@
+#
+# Copyright 2024 Ettus Research, a National Instruments Brand
+#
+# SPDX-License-Identifier: LGPL-3.0-or-later
+#
+# Description:
+#   100 GbE Placement Constraints for QSFP port 0.
+#
+
+set 100g_mac_0 [get_cells -hierarchical -filter { PRIMITIVE_TYPE == ADVANCED.MAC.CMACE4 && PARENT =~  "*eth_qsfp0*" } ]
+set_property LOC CMACE4_X0Y1 $100g_mac_0
diff --git a/lib/rfnoc/transport_adapters/rfnoc_ta_x4xx_eth/constraints/qsfp_100gbe_port1.xdc b/lib/rfnoc/transport_adapters/rfnoc_ta_x4xx_eth/constraints/qsfp_100gbe_port1.xdc
new file mode 100644
index 0000000..8ae31cb
--- /dev/null
+++ b/lib/rfnoc/transport_adapters/rfnoc_ta_x4xx_eth/constraints/qsfp_100gbe_port1.xdc
@@ -0,0 +1,11 @@
+#
+# Copyright 2024 Ettus Research, a National Instruments Brand
+#
+# SPDX-License-Identifier: LGPL-3.0-or-later
+#
+# Description:
+#   100 GbE Placement Constraints for QSFP port 1.
+#
+
+set 100g_mac_1 [get_cells -hierarchical -filter { PRIMITIVE_TYPE == ADVANCED.MAC.CMACE4 && PARENT =~  "*eth_qsfp1*" } ]
+set_property LOC CMACE4_X0Y0 $100g_mac_1